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35-44 – the first stage of the middle age
• The first signs of the deterioration of the physical shape (accumulation of fat, overweight). The deterioration of the physical shape is not obvious and the accumulation of fat occurs steadily, although the body weight may remain stable. Nevertheless, individuals face the problem of difficulties concerning the maintenance of a good physical shape. Physical exercises and training do not lead to fast and obvious outcomes as they used to in the young adulthood.
• The loss of skin elasticity is the characteristic that becomes obvious by the early 40s.
• Beginning of graying of the hair marks the beginning of the middle age. Normally, occurs in the late 30s – early 40s of an individual.
45-54 – the second stage of the middle age
• The deterioration of the physical shape carries on and becomes more obvious compared to the first stage. The body weight often increases by 5-10 kilograms.
• The increase of the risk of development of age diseases, like cardio-vascular diseases. The risk increases along with the age of an individual. Middle age adults after 40, especially in the late 40s are likely to face problems with their heart, especially if they suffer from obesity or overweight.
• The sexual activity of middle age adults decreases
55-65 – the third stage of the middle age
• The further deterioration of the physical shape. Problems with vision, hearing, graying of hair is almost complete.
• The abrupt decline in fertility and the drop of sexual activity of middle age adults. Menopause occurs to women in the late 40s – early 50s leads to their drop fertility after 55.

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References:
MacDonald, K., & Hershberger, S. (2005). “Theoretical Issues in the Study of Evolution and Development.” In R. Burgess and K. MacDonald (Eds.), Evolutionary Perspectives on Human Development, 2nd edition, pp. 21–72. Thousand Oaks, CA: Sage.